Daniel Fletcher

Professor of Bioengineering
Keywords: mechanics, materials
Research Areas: bioengineering, optical and force microscopy, microfabrication, mechanical properties of cells, stem cell
Website: http://fletchlab.berkeley.edu/

Research Description:

My laboratory studies the mechanics and dynamics of cell movements on the purified protein, single cell, and tissue levels. For these studies, we are developing new instruments to quantify cell and molecular mechanics based on optical microscopy, force microscopy, and microfabrication.

Selected Publications:

  • J. W. Shaevitz and D. A. Fletcher, “Load fluctuations drive actin network growth”, Proceedings of the National Academy of Science USA, vol. 104, no. 40, pp. 15688-92, 2007.
  • O. Chaudhuri, S. H. Parekh, and D. A. Fletcher, “Reversible stress-softening of dendritic actin networks”, Nature, vol. 445, no. 7125, pp. 295-298, 2007.
  • W. A. Lam, M. J. Rosenbluth, and D. A. Fletcher, “Chemotherapy exposure increases leukemia cell stiffness”, Blood, vol. 109, no. 8, pp. 3505-8, 2007.
  • C. M. Nelson, M. M. van Duijn, J. L. Inman, D. A. Fletcher, and M. J. Bissell, “Tissue geometry determines sites of branching morphogenesis in organotypic cultures”, Science, vol. 314, no. 5797, pp. 298-300, 2006.
  • A. P. Liu and D. A. Fletcher, “Actin polymerization serves as a membrane domain switch in model lipid bilayers”, Biophysical Journal, epublished ahead of print on September 8, 2006.
  • M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Force microscopy of non-adherent cells: a comparison of leukemia cell deformability”, Biophysical Journal, vol. 90, no. 8, pp. 2994-3003, 2006.
  • S. H. Parekh, O. Chaudhuri, J. A. Theriot, and D. A. Fletcher, “Loading history determines the velocity of actin network growth”, Nature Cell Biology, vol. 7, no. 12, pp. 1119-1123, 2005.
  • W. R. Hansen, O. Tulyathan, S. C. Dawson, W. Z. Cande, and D.A. Fletcher, “Giardia lamblia attachment force is insensitive to surface treatments”, Eukaryotic Cell, vol. 5, no. 4, pp. 781-783, 2006.
  • J. W. Shaevitz, J. Y. Lee, and D. A. Fletcher, “Spiroplasma swim by a processive change in body helicity”, Cell, vol. 122, pp. 941-945, 2005.
  • A. P. Liu and D. A. Fletcher, “Photopatterning of actin filament structures”, Nano Letters, vol. 5, no. 4, pp. 625-628, 2005.

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